Children born by planned caesarean section are 21% more likely to develop acute lymphoblastic leukemia (all), a childhood cancer, than their vagina was born into the vagina, a new study finds.
This study, conducted in Sweden, is consistent with previous studies that found links between all risks and c-sections in children. Recent research, including this latest study, specifically links the majority of its risks to the planned C-section. In this study, the planned C section was defined as being initiated prior to labour.
Crucially, however, the risk of all children in general and childhood cancer remains low overall, said Joseph Weemels, a professor of population and public health sciences at the University of Southern California, who was not involved in the job. In the United States, approximately 4.8 people are diagnosed with leukemia per year in 100,000 children. Therefore, the relative risks are [for ALL] For babies born by planned caesarean section, Wiemels warned that the risk was “still relatively low” overall.
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Caesarean sections are “an essential and life-saving component of modern obstetric care,” Christina Evmorfia-Kampitsi, the lead research author of Christina Evmorfia-Kampitsi, a postdoctoral researcher at the Carolina Institute, told Live Science in an email. Some people give birth by C-sections planned for maternal conditions such as pre-lammosis, or to protect the health of the baby, for example because they are not getting enough oxygen.
“Our findings should not be the source of concern if the procedure is medically indicated,” Evmorfia-Kampitsi said.
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What’s unique about this study is that it was published in the International Journal of Cancer on July 4th, and found that researchers manage different characteristics of mothers and newborns, and that all risks for children born by planned caesarean sections are still high.
“Thanks to the wealth of Swedish registration data, we were able to adjust to a wide range of mothers, pregnancy and newborns. [newborn] Factors,” Evmorfia-Kampitsi said. [C-section] in the first place. ”
Wiemels said it was important to control these other factors. He said this is because mothers over 35 are also associated with the increased risk of everything developing. There is also a link between birth defects and all risks and environmental factors such as radiation. However, since everything occurs at such a young age, researchers have been investigating prenatal and immediate postnatal factors that could lead to their development.
For this study, the researchers looked at the birth modes of vaginal, planned caesarean sections, or unplanned caesarean sections, at the 20 years of births of over 2.4 million people in Sweden. Data on the weight of the newborn, birth defects, and whether the mother was overweight or obese, diabetes or pre-lamp disease were also examined. Furthermore, they saw all incidence rates in these children over time.
The researchers also grouped children based on the decade they were born to explain changes in obstetric practice, the percentage of C-sections, changes in how childhood cancer is diagnosed, and other factors that may change over time, Evmorfia-Kampitsi said.
Over 375,000 of approximately 15% of children were born by a C-section containing a plan of approximately 213,000 and started before the start of work. Of the 2.4 million children, approximately 1,200 (0.05%), have all developed.
All risks were higher than vaginal born patients among babies born in all types of c-sections. The risk associated with unplanned C-sections was slightly increased, which began after Laborgh, but was at the highest risk among those born by planned caesarean sections that began before labor began.
The planned C-section was further divided into “planned” and “acute”, the latter meaning there was some immediate medical need, such as fetal distress. These acute cases did not appear to have any association with an increased risk of cancer, but with only a handful of such cases it is difficult to draw solid conclusions.
“These results should be interpreted with caution,” Evmorfia-Kampitsi said. “Our main findings remain an increased risk associated with planned Prilaball CS.”
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The cause of concern?
All childhood was diagnosed most frequently in children under 5 years of age, and this finding was statistically significant for children in this age group. In other words, all relationships with the planned C section seemed most clear in its age range, Evmorfia-Kampitsi said.
The study “may tell us about the risk of leukemia and the mechanisms behind that risk,” suggested Weemels.
On that front, it is known that there are genetic mutations that develop before birth and that children can be born in preleukemia cells. But Erin Marcott, an associate professor in the Department of Pediatric Epidemiology and Clinical Research at the University of Minnesota, who was not involved in the new research, says that children who have more children born than they actually develop full-scale cancer are born in these cells.
“Most children are likely to be able to cull these cells,” Marcott told Live Science via email. But what do you think?
There are two main theories as to how this works and how these mechanisms are compromised by the planned C section. The first suggests that babies born through the C-section may miss exposure to vaginal duct microorganisms and promote a more “tolerant” environment for leukemia to develop, Weemels said. Babies born through a C-section that begins before labor are exposed to fewer microorganisms than microorganisms that begin after labor.
The second hypothesis is that babies born with planned C-sections miss short-term exposure to stress hormones that they usually encounter during labor. These hormones are thought to help eliminate pre-leukemia cells.
In addition to the idea, the fact that corticosteroids are the mainstay in childhood leukemia treatment and resemble body-made cortisol. Furthermore, Kjeld Schmiegelow, a clinical professor at the University of Copenhagen, hypothesizes that stress caused by infancy infections can help eliminate pre-leukemia cells.
Whatever the root cause of the link, the absolute risk of all remains low even in the context of the C section. But that is potentially something that doctors should consider, Evmorfia-Kampitsi said. “It is important to be aware of potential long-term outcomes if CS is considered without clear medical indications,” she said.
Still, countries with a higher rate of caesarean sections do not always have all proportions, so more research into the relationship between everything and planned caesarean sections is needed. Since the study was conducted in Sweden, “it is plausible, but not confirmed, that other populations with various demographic characteristics and environmental exposures could produce similar outcomes,” Daee said.
This article is for informational purposes only and is not intended to provide medical advice.
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